A Zebrafish In Vivo Phenotypic Assay to Identify 3-Aminothiophene-2-Carboxylic Acid-Based Angiogenesis Inhibitors

Small molecules that inhibit angiogenesis are attractive drug candidates for cancer, retinopathies, and age-related macular degeneration. In vivo, phenotypic screening in zebrafish (Danio rerio) emerges as a powerful methodology to identify and optimize novel compounds with pharmacological activity....

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Detalhes bibliográficos
Publicado no:Assay Drug Dev Technol
Main Authors: Papakyriakou, Athanasios, Kefalos, Panagiotis, Sarantis, Panagiotis, Tsiamantas, Christos, Xanthopoulos, Kleanthis P., Vourloumis, Dionisios, Beis, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270155/
https://ncbi.nlm.nih.gov/pubmed/25506802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2014.606
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