Redox-Sensitive Structure and Function of the First Extracellular Loop of the Cell–Cell Contact Protein Claudin-1: Lessons from Molecular Structure to Animals

The paracellular cleft within epithelia/endothelia is sealed by tight junction (TJ) proteins. Their extracellular loops (ECLs) are assumed to control paracellular permeability and are targets of pathogenes. We demonstrated that claudin-1 is crucial for paracellular tightening. Its ECL1 is essential...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Dabrowski, Sebastian, Staat, Christian, Zwanziger, Denise, Sauer, Reine-Solange, Bellmann, Christian, Günther, Ramona, Krause, Eberhard, Haseloff, Reiner Fritz, Rittner, Heike, Blasig, Ingolf Ernst
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Original Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270150/
https://ncbi.nlm.nih.gov/pubmed/24988310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5706
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