Human PSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice

Seizure disorders debilitate more than 65,000,000 people worldwide, with temporal lobe epilepsy (TLE) being the most common form. Previous studies have shown that transplantation of GABA-releasing cells results in suppression of seizures in epileptic mice. Derivation of interneurons from human PSC h...

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Udgivet i:Cell Stem Cell
Main Authors: Cunningham, Miles, Cho, Jun-Hyeong, Leung, Amanda, Savvidis, George, Ahn, Sandra, Moon, Minho, Lee, Paula KJ, Han, Jason J., Azimi, Nima, Kim, Kwang-Soo, Bolshakov, Vadim Y., Chung, Sangmi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270101/
https://ncbi.nlm.nih.gov/pubmed/25517465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.10.006
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