Human PSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice

Seizure disorders debilitate more than 65,000,000 people worldwide, with temporal lobe epilepsy (TLE) being the most common form. Previous studies have shown that transplantation of GABA-releasing cells results in suppression of seizures in epileptic mice. Derivation of interneurons from human PSC h...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Cunningham, Miles, Cho, Jun-Hyeong, Leung, Amanda, Savvidis, George, Ahn, Sandra, Moon, Minho, Lee, Paula KJ, Han, Jason J., Azimi, Nima, Kim, Kwang-Soo, Bolshakov, Vadim Y., Chung, Sangmi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270101/
https://ncbi.nlm.nih.gov/pubmed/25517465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.10.006
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