STAT3 restrains RANK- and TLR4-mediated signaling by suppressing expression of the E2 ubiquitin ligase Ubc13

The transcriptional regulator STAT3 curbs pro-inflammatory cytokine production mediated by NF-κB signaling in innate immune cells, yet the mechanism by which this occurs has been unclear. Here we identify STAT3 as a pivotal negative regulator of Ubc13, an E2 ubiquitin-conjugating enzyme that facilit...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zhang, Huiyuan, Hu, Hongbo, Greeley, Nathaniel, Jin, Jin, Matthews, Allison J., Ohashi, Erika, Caetano, Mauricio S., Li, Haiyan S., Wu, Xuefeng, Mandal, Pijus K., McMurray, John S., Moghaddam, Seyed Javad, Sun, Shao-Cong, Watowich, Stephanie S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270087/
https://ncbi.nlm.nih.gov/pubmed/25503582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6798
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