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Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells
Epigenetic modifiers are an emerging class of anti-tumor drugs, potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune diseases has been little explored. We report that a short treatment with I-BET151, a small-molecule inhibitor of a family of bromodomain-containing...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4270084/ https://ncbi.nlm.nih.gov/pubmed/25407682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04631 |
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