GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

A single, low dose of the NMDA receptor antagonist ketamine produces rapid antidepressant actions in treatment-resistant depressed patients. Understanding the cellular mechanisms underlying this will lead to new therapies for treating major depression. NMDARs are heteromultimeric complexes formed th...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Miller, Oliver H, Yang, Lingling, Wang, Chih-Chieh, Hargroder, Elizabeth A, Zhang, Yihui, Delpire, Eric, Hall, Benjamin J
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2014
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270067/
https://ncbi.nlm.nih.gov/pubmed/25340958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03581
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