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Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications

BACKGROUND: Nanobodies (Nbs) have proved their great value as therapeutic molecules and clinical diagnostic tools. Although the routine procedure to obtain Nbs is to immunize camels with antigens, it is unavailable to immunize a camel when the antigens are highly toxic, pathogenic or nonimmunogenic....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Transl Med
Prif Awduron: Yan, Junrong, Li, Guanghui, Hu, Yonghong, Ou, Weijun, Wan, Yakun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269866/
https://ncbi.nlm.nih.gov/pubmed/25496223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0343-6
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