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Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications

BACKGROUND: Nanobodies (Nbs) have proved their great value as therapeutic molecules and clinical diagnostic tools. Although the routine procedure to obtain Nbs is to immunize camels with antigens, it is unavailable to immunize a camel when the antigens are highly toxic, pathogenic or nonimmunogenic....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Transl Med
Päätekijät: Yan, Junrong, Li, Guanghui, Hu, Yonghong, Ou, Weijun, Wan, Yakun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269866/
https://ncbi.nlm.nih.gov/pubmed/25496223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0343-6
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