Essential Structural and Functional Roles of the Cmr4 Subunit in RNA Cleavage by the Cmr CRISPR-Cas Complex

The Cmr complex is the multi-subunit effector complex of the Type III-B CRISPR-Cas immune system. The Cmr complex recognizes a target RNA through base pairing with the integral CRISPR RNA (crRNA) and cleaves the target at multiple regularly spaced locations within the complementary region. To unders...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Ramia, Nancy F., Spilman, Michael, Tang, Li, Shao, Yaming, Elmore, Joshua, Hale, Caryn, Cocozaki, Alexis, Bhattacharya, Nilakshee, Terns, Rebecca M., Terns, Michael P., Li, Hong, Stagg, Scott M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269474/
https://ncbi.nlm.nih.gov/pubmed/25482566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.11.007
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