IMPAIRMENT OF HUMAN CYP1A2-MEDIATED XENOBIOTIC METABOLISM BY ANTLEY-BIXLER SYNDROME VARIANTS OF CYTOCHROME P450 OXIDOREDUCTASE()

Y459H and V492E mutations of cytochrome P450 reductase (CYPOR) cause Antley-Bixler Syndrome due to diminished binding of the FAD cofactor. To address whether these mutations impaired the interaction with drug metabolizing CYPs, a bacterial model of human liver expression of CYP1A2 and CYPOR was impl...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Biochem Biophys
Hauptverfasser: Kranendonk, Michel, Marohnic, Christopher C., Panda, Satya P., Duarte, Maria Paula, Oliveira, José Santos, Masters, Bettie Sue Siler, Rueff, José
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269338/
https://ncbi.nlm.nih.gov/pubmed/18455494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.04.014
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