Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion

Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving the templated conversion of the normal cellular prion protein (PrP(C)) to a pathogenic misfolded conformation. Templated conversion has been modelled in several in vitro assays, inclu...

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Bibliographische Detailangaben
Veröffentlicht in:J Gen Virol
Hauptverfasser: Henderson, Davin M., Davenport, Kristen A., Haley, Nicholas J., Denkers, Nathaniel D., Mathiason, Candace K., Hoover, Edward A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for General Microbiology 2015
Schlagworte:
TSE Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268821/
https://ncbi.nlm.nih.gov/pubmed/25304654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.069906-0
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