Glucocorticosteroids trigger reactivation of human cytomegalovirus from latently infected myeloid cells and increase the risk for HCMV infection in D+R+ liver transplant patients

Graft rejection in transplant patients is managed clinically by suppressing T-cell function with immunosuppressive drugs such as prednisolone and methylprednisolone. In such immunocompromised hosts, human cytomegalovirus (HCMV) is an important opportunistic pathogen and can cause severe morbidity an...

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Bibliographische Detailangaben
Veröffentlicht in:J Gen Virol
Hauptverfasser: Van Damme, Ellen, Sauviller, Sarah, Lau, Betty, Kesteleyn, Bart, Griffiths, Paul, Burroughs, Andrew, Emery, Vincent, Sinclair, John, Van Loock, Marnix
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for General Microbiology 2015
Schlagworte:
Animal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268819/
https://ncbi.nlm.nih.gov/pubmed/25312585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.069872-0
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