Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

Obesity is associated with a cluster of metabolic disorders, low-grade inflammation and altered gut microbiota. Whether host metabolism is controlled by intestinal innate immune system and the gut microbiota is unknown. Here we report that inducible intestinal epithelial cell-specific deletion of My...

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Pubblicato in:Nat Commun
Autori principali: Everard, Amandine, Geurts, Lucie, Caesar, Robert, Van Hul, Matthias, Matamoros, Sébastien, Duparc, Thibaut, Denis, Raphael G. P., Cochez, Perrine, Pierard, Florian, Castel, Julien, Bindels, Laure B., Plovier, Hubert, Robine, Sylvie, Muccioli, Giulio G., Renauld, Jean-Christophe, Dumoutier, Laure, Delzenne, Nathalie M., Luquet, Serge, Bäckhed, Fredrik, Cani, Patrice D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268705/
https://ncbi.nlm.nih.gov/pubmed/25476696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6648
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