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Calcium-like Action of Phenethylbiguanide and Related Compounds: Inhibition of Pyruvate Kinase

Pyruvate kinase (EC 2.7.1.40) is inhibited by phenethylbiguanide. The kinetics of inhibition are competitive between biguanide and divalent, but not monovalent, metal cation activators of the enzyme; biguanide inhibition thus resembles inhibition by Ca(++). Alteration of either the polar or nonpolar...

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Detalhes bibliográficos
Main Authors: Davidoff, Frank, Carr, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 1972
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC426840/
https://ncbi.nlm.nih.gov/pubmed/4505673
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