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Phenethylbiguanide and the inhibition of hepatic gluconeogenesis in the guinea pig

1. Phenethylbiguanide inhibits the synthesis of phosphoenolpyruvate from malate or 2-oxoglutarate by isolated guinea-pig liver mitochondria. This inhibition is time- and concentration-dependent, with the maximum decrease in the rate of phosphoenolpyruvate synthesis (80%) evident after 10min of incub...

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Detalhes bibliográficos
Main Authors: Ogata, Korechika, Jomain-Baum, Mireille, Hanson, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 1974
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168463/
https://ncbi.nlm.nih.gov/pubmed/4462575
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