Multi-Generational Pharmacophore Modeling for Ligands to the Cholane Steroid-Recognition Site in the β(1) Modulatory Subunit of the BK(Ca) Channel

Large conductance, voltage- and Ca(2+)-gated K(+) (BK(Ca)) channels play a critical role in smooth muscle contractility and thus represent an emerging therapeutic target for drug development to treat vascular disease, gastrointestinal, bladder and uterine disorders. Several compounds are known to ta...

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Detalhes bibliográficos
Publicado no:J Mol Graph Model
Main Authors: McMillan, Jacob E., Bukiya, Anna N., Terrell, Camisha L., Patil, Shivaputra A., Miller, Duane D., Dopico, Alex M., Parrill, Abby L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268273/
https://ncbi.nlm.nih.gov/pubmed/25459769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2014.10.008
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