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Structural determinants of monohydroxylated bile acids to activate β(1) subunit-containing BK channels

Lithocholate (LC) (10–300 μM) in physiological solution is sensed by vascular myocyte large conductance, calcium- and voltage-gated potassium (BK) channel β(1) accessory subunits, leading to channel activation and arterial dilation. However, the structural features in steroid and target that determi...

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Detalhes bibliográficos
Main Authors: Bukiya, Anna N., McMillan, Jacob, Parrill, Abby L., Dopico, Alejandro M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563214/
https://ncbi.nlm.nih.gov/pubmed/18650555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800286-JLR200
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