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Netrin-1 Abrogates Ischemia Reperfusion-induced Cardiac Mitochondrial Dysfunction via Nitric Oxide-dependent Attenuation of NOX4 Activation and Recoupling of NOS

Despite an established role of mitochondrial dysfunction in cardiac ischemia reperfusion (I/R) injury, the upstream activators have remained incompletely defined. We have recently identified an innovative role of exogenously applied netrin-1 in cardioprotection, which is mediated by increased nitric...

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Siu, Kin Lung, Lotz, Christopher, Ping, Peipei, Cai, Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268247/
https://ncbi.nlm.nih.gov/pubmed/25066694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.07.005
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