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Suppression of TET1-Dependent DNA Demethylation is Essential for KRAS-Mediated Transformation
Hypermethylation-mediated tumor suppressor gene (TSG) silencing is a central epigenetic alteration in RAS-dependent tumorigenesis. Ten-eleven translocation (TET) enzymes can depress DNA methylation by hydroxylation of 5-methylcytosine (5mC) bases to 5-hydroxymethylcytosine (5hmC). Here we report tha...
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| Publicado no: | Cell Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4268240/ https://ncbi.nlm.nih.gov/pubmed/25466250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.063 |
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