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Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells
The MAPK phosphatase MKP1 (DUSP1) is overexpressed in many human cancers, including chemoresistant and radioresistant breast cancer cells, but its functional contributions in these settings are unclear. Here we report that after cell irradiation MKP1 translocates into mitochondria, where it prevents...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4267894/ https://ncbi.nlm.nih.gov/pubmed/25377473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0844 |
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