The AGC kinase serum- and glucocorticoid-regulated kinase 1 (SGK1) regulates T(H)1 and T(H)2 differentiation downstream of mTORC2

Serum- and glucocorticoid-regulated kinase 1 (SGK1) is an AGC kinase that regulates membrane sodium channel expression in renal tubular cells in an mTORC2-dependent manner. We hypothesized that SGK1 might represent a novel mTORC2-dependent regulator of T cell differentiation and function. Here we de...

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Pubblicato in:Nat Immunol
Autori principali: Heikamp, Emily B., Patel, Chirag H., Collins, Sam, Waickman, Adam, Oh, Min-Hee, Sun, Im-Hong, Illei, Peter, Sharma, Archna, Naray-Fejes-Toth, Aniko, Fejes-Toth, Geza, Sen, Jyoti, Horton, Maureen R., Powell, Jonathan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267697/
https://ncbi.nlm.nih.gov/pubmed/24705297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2867
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