Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients

OBJECTIVES: Polymorphisms in the lysosomal transporter encoded by the pfcrt gene directly impact on Plasmodium falciparum susceptibility to aminoquinolines. The Lys76Thr mutation is the critical change conferring chloroquine resistance in vitro and in vivo, but always occurs with additional non-syno...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Antimicrob Chemother
Main Authors: Gadalla, Nahla B., Malmberg, Maja, Adam, Ishag, Oguike, Mary C., Beshir, Khalid, Elzaki, Salah-Eldin, Mukhtar, Izdihar, Gadalla, Amal A., Warhurst, David C., Ngasala, Billy, Mårtensson, Andreas, El-Sayed, Badria B., Gil, J. Pedro, Sutherland, Colin J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267505/
https://ncbi.nlm.nih.gov/pubmed/25253286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku358
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