Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties

Although the majority of Alzheimer's disease (AD) cases are sporadic, about 5% of cases are inherited in an autosomal dominant pattern as familial AD (FAD) and manifest at an early age. Mutations in the presenilin 1 (PSEN1) gene account for the majority of early-onset FAD. Here, we describe the...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Stem Cells Dev
Egile Nagusiak: Mahairaki, Vasiliki, Ryu, Jiwon, Peters, Ann, Chang, Qing, Li, Tong, Park, Tea Soon, Burridge, Paul W., Talbot, Conover C., Asnaghi, Laura, Martin, Lee J., Zambidis, Elias T., Koliatsos, Vassilis E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Mary Ann Liebert, Inc. 2014
Gaiak:
Original Research Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267410/
https://ncbi.nlm.nih.gov/pubmed/25027006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0511
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