Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis

For more than half a century, transition state theory has provided a useful framework for understanding the origins of enzyme catalysis. As proposed by Pauling, enzymes accelerate chemical reactions by binding transition states tighter than substrates, thereby lowering the activation energy compared...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Burschowsky, Daniel, van Eerde, André, Ökvist, Mats, Kienhöfer, Alexander, Kast, Peter, Hilvert, Donald, Krengel, Ute
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267393/
https://ncbi.nlm.nih.gov/pubmed/25422475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408512111
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