UbcH7 regulates 53BP1 stability and DSB repair

DNA double-strand break (DSB) repair is not only key to genome stability but is also an important anticancer target. Through an shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ube2L3), a ubiquitin E2 enzyme, as a critical player in DSB repair. UbcH7...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Han, Xiangzi, Zhang, Lei, Chung, Jinsil, Mayca Pozo, Franklin, Tran, Amanda, Seachrist, Darcie D., Jacobberger, James W., Keri, Ruth A., Gilmore, Hannah, Zhang, Youwei
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267386/
https://ncbi.nlm.nih.gov/pubmed/25422456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408538111
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