Disruption of FAT10–MAD2 binding inhibits tumor progression

FAT10 (HLA-F-adjacent transcript 10) is a ubiquitin-like modifier that is commonly overexpressed in various tumors. It was found to play a role in mitotic regulation through its interaction with mitotic arrest-deficient 2 (MAD2). Overexpression of FAT10 promotes tumor growth and malignancy. Here, we...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Theng, Steven Setiawan, Wang, Wei, Mah, Way-Champ, Chan, Cheryl, Zhuo, Jingli, Gao, Yun, Qin, Haina, Lim, Liangzhong, Chong, Samuel S., Song, Jianxing, Lee, Caroline G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267366/
https://ncbi.nlm.nih.gov/pubmed/25422469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403383111
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