Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MSP Domain as Revealed by NMR and MD Simulations

T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS). Here using CD, NMR and molecular dynamics (MD) simulations, we characterized the structure, stability, dynamics and binding capacity o...

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Main Authors: Lua, Shixiong, Qin, Haina, Lim, Liangzhong, Shi, Jiahai, Gupta, Garvita, Song, Jianxing
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206076/
https://ncbi.nlm.nih.gov/pubmed/22069488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027072
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