Molecular architecture of the αβ T cell receptor–CD3 complex

αβ T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that comprises the CD3εγ, CD3εδ, and CD3ζζ dimers. How...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Birnbaum, Michael E., Berry, Richard, Hsiao, Yu-Shan, Chen, Zhenjun, Shingu-Vazquez, Miguel A., Yu, Xiaoling, Waghray, Deepa, Fischer, Suzanne, McCluskey, James, Rossjohn, Jamie, Walz, Thomas, Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267357/
https://ncbi.nlm.nih.gov/pubmed/25422432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420936111
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