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Chemical Mutagenesis at the Phosphoribosyltransferase Locus in Cultured Human Lymphoblasts

The presence of selectable genetic markers in long-term human lymphoblast cultures would facilitate cell hybridization experiments on the biosynthesis of immunoglobulins, as well as other studies. This work reports the induction with ethylmethane sulfonate of 6-thioguanine - resistant, phosphoribosy...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sato, Koki, Slesinski, Ronald S., Littlefield, John W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1972
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4504337/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.5.1244
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