Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia

INTRODUCTION: Activating calcium sensing receptor (CaSR) mutations cause autosomal dominant hypocalcemia (ADH) characterized by low serum calcium, inappropriately low PTH and relative hypercalciuria. Four activating CaSR mutations cause additional renal wasting of sodium, chloride and other salts, a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Letz, Saskia, Haag, Christine, Schulze, Egbert, Frank-Raue, Karin, Raue, Friedhelm, Hofner, Benjamin, Mayr, Bernhard, Schöfl, Christof
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266668/
https://ncbi.nlm.nih.gov/pubmed/25506941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115178
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares