Amino Alcohol- (NPS-2143) and Quinazolinone-Derived Calcilytics (ATF936 and AXT914) Differentially Mitigate Excessive Signalling of Calcium-Sensing Receptor Mutants Causing Bartter Syndrome Type 5 and Autosomal Dominant Hypocalcemia

INTRODUCTION: Activating calcium sensing receptor (CaSR) mutations cause autosomal dominant hypocalcemia (ADH) characterized by low serum calcium, inappropriately low PTH and relative hypercalciuria. Four activating CaSR mutations cause additional renal wasting of sodium, chloride and other salts, a...

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Vydáno v:PLoS One
Hlavní autoři: Letz, Saskia, Haag, Christine, Schulze, Egbert, Frank-Raue, Karin, Raue, Friedhelm, Hofner, Benjamin, Mayr, Bernhard, Schöfl, Christof
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266668/
https://ncbi.nlm.nih.gov/pubmed/25506941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115178
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