Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43(−) Embryonic Precursor

Definitive hematopoietic stem cells (HSCs) develop in the aorta gonad mesonephros (AGM) region in a stepwise manner. Type I pre-HSCs express CD41 but lack CD45 expression, which is subsequently upregulated in type II pre-HSCs prior to their maturation into definitive HSCs. Here, using ex vivo modeli...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Rybtsov, Stanislav, Batsivari, Antoniana, Bilotkach, Kateryna, Paruzina, Daria, Senserrich, Jordi, Nerushev, Oleg, Medvinsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266012/
https://ncbi.nlm.nih.gov/pubmed/25241746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.07.009
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