Codon-optimized Human Sodium Iodide Symporter (opt-hNIS) as a Sensitive Reporter and Efficient Therapeutic Gene

To generate a more efficient in vivo reporter and therapeutic gene, we optimized the coding sequence of the human sodium/iodide symporter (NIS) gene by replacing NIS DNA codons from wild type to new codons having the highest usage in human gene translation. The Codon Adaptation Index (CAI), represen...

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Pubblicato in:Theranostics
Autori principali: Kim, Young-Hwa, Youn, Hyewon, Na, Juri, Hong, Kee-Jong, Kang, Keon Wook, Lee, Dong Soo, Chung, June-Key
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265750/
https://ncbi.nlm.nih.gov/pubmed/25553100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.10062
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