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Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire

KAT6 histone acetyltransferases (HATs) are highly conserved in eukaryotes and have been shown to play important roles in transcriptional regulation. Here, we demonstrate that the Drosophila KAT6 Enok acetylates histone H3 Lys 23 (H3K23) in vitro and in vivo. Mutants lacking functional Enok exhibited...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Huang, Fu, Paulson, Ariel, Dutta, Arnob, Venkatesh, Swaminathan, Smolle, Michaela, Abmayr, Susan M., Workman, Jerry L.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265678/
https://ncbi.nlm.nih.gov/pubmed/25512562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249730.114
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