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PTIP associates with Artemis to dictate DNA repair pathway choice
PARP inhibitors (PARPis) are being used in patients with BRCA1/2 mutations. However, doubly deficient BRCA1(−/−)53BP1(−/−) cells or tumors become resistant to PARPis. Since 53BP1 or its known downstream effectors, PTIP and RIF1 (RAP1-interacting factor 1 homolog), lack enzymatic activities directly...
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| Publicado no: | Genes Dev |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4265673/ https://ncbi.nlm.nih.gov/pubmed/25512557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252478.114 |
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