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Ploidy Dictates Repair Pathway Choice under DNA Replication Stress

This study reports an unusual ploidy-specific response to replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in yeast. The corresponding mouse allele, Mcm4(Chaos3), predisposes mice to mammary gland tumors. While mcm4(Chaos3) causes replication stress in bot...

詳細記述

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書誌詳細
主要な著者: Li, Xin Chenglin, Tye, Bik K.
フォーマット: Artigo
言語:Inglês
出版事項: Genetics Society of America 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070513/
https://ncbi.nlm.nih.gov/pubmed/21242538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.125450
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