Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists

BACKGROUND: There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage. Here, we investigated whether epigenetic silencing of Wnt antagonists is the b...

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Udgivet i:BMC Cancer
Main Authors: Silva, Ana-Luisa, Dawson, Sarah N, Arends, Mark J, Guttula, Kiran, Hall, Nigel, Cameron, Ewen A, Huang, Tim H-M, Brenton, James D, Tavaré, Simon, Bienz, Mariann, Ibrahim, Ashraf EK
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265460/
https://ncbi.nlm.nih.gov/pubmed/25432628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-891
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