Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A

BACKGROUND: There is an urgent need for improved vaccines to protect against tuberculosis. The currently available vaccine Bacille Calmette-Guerin (BCG) has varying immunogenicity and efficacy across different populations for reasons not clearly understood. MVA85A is a modified vaccinia virus expres...

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Publicat a:BMC Infect Dis
Autors principals: Tanner, Rachel, Kakalacheva, Kristina, Miller, Ellen, Pathan, Ansar A, Chalk, Rod, Sander, Clare R, Scriba, Tom, Tameris, Michelle, Hawkridge, Tony, Mahomed, Hassan, Hussey, Greg, Hanekom, Willem, Checkley, Anna, McShane, Helen, Fletcher, Helen A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265419/
https://ncbi.nlm.nih.gov/pubmed/25466778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-014-0660-7
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