Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations

Ewing sarcoma is a primary bone tumor initiated by EWSR1–ETS gene fusions. To identify secondary genetic lesions that contribute to tumor progression, we performed whole-genome sequencing of 112 Ewing sarcoma samples and matched germline DNA. Overall, Ewing sarcoma tumors had relatively few single-n...

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Publicat a:Cancer Discov
Autors principals: Tirode, Franck, Surdez, Didier, Ma, Xiaotu, Parker, Matthew, Le Deley, Marie Cécile, Bahrami, Armita, Zhang, Zhaojie, Lapouble, Eve, Grossetête-Lalami, Sandrine, Rusch, Michael, Reynaud, Stéphanie, Rio-Frio, Thomas, Hedlund, Erin, Wu, Gang, Chen, Xiang, Pierron, Gaelle, Oberlin, Odile, Zaidi, Sakina, Lemmon, Gordon, Gupta, Pankaj, Vadodaria, Bhavin, Easton, John, Gut, Marta, Ding, Li, Mardis, Elaine R., Wilson, Richard K., Shurtleff, Sheila, Laurence, Valérie, Michon, Jean, Marec-Bérard, Perrine, Gut, Ivo, Downing, James, Dyer, Michael, Zhang, Jinghui, Delattre, Olivier
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264969/
https://ncbi.nlm.nih.gov/pubmed/25223734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0622
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