E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation

Malignant melanoma is highly lethal due to its aggressive invasive properties and metastatic dissemination. The transcription factor E2F1 is crucial for melanoma progression through poorly understood mechanisms. Here, we show that the miR-224/miR-452 cluster is significantly increased in advanced me...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Knoll, Susanne, Fürst, Katharina, Kowtharapu, Bhavani, Schmitz, Ulf, Marquardt, Stephan, Wolkenhauer, Olaf, Martin, Hubert, Pützer, Brigitte M
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Scientific Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264934/
https://ncbi.nlm.nih.gov/pubmed/25341426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439392
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