Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3

BACKGROUND: The pro-inflammatory cytokine interleukin-6 (IL6) promotes colorectal cancer (CRC) development. It is also known to regulate cytochrome P450 (CYP450) enzymes, which are involved in CRC tumour initiation and promotion via activation of chemical carcinogens. Here, IL6 regulation of CYP450...

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Detalles Bibliográficos
Publicado en:Br J Cancer
Autores principales: Patel, S A A, Bhambra, U, Charalambous, M P, David, R M, Edwards, R J, Lightfoot, T, Boobis, A R, Gooderham, N J
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264448/
https://ncbi.nlm.nih.gov/pubmed/25333344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.540
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