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B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients

We have developed a microarray to study the expression of L-chain V genes (V(L) genes) in healthy and SLE patient peripheral κ- and λ-sorted B cells. In all repertoires tested, one V(L) gene accounts for over 10% of all gene V(L) expression, consistent with positive selection acting on L-chains. Whi...

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Detalles Bibliográficos
Publicado en:Mol Immunol
Main Authors: Schoettler, Nathan, Ni, Dongyao, Weigert, Martin
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264353/
https://ncbi.nlm.nih.gov/pubmed/22516082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.03.028
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