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A novel method for detection of HBVcccDNA in hepatocytes using rolling circle amplification combined with in situ PCR

BACKGROUND: Intrahepatic hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the original template for HBV replication. The persistence of cccDNA is responsible for the recurrence of HBV infection. The detection of cccDNA can help the development of new antiviral drugs against HBV rep...

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Publicado en:BMC Infect Dis
Autores principales: Zhong, Yanwei, Hu, Shuangye, Xu, Chen, Zhao, Yulai, Xu, Dongping, Zhao, Yanqing, Zhao, Jingmin, Li, Zhibin, Zhang, Xiuchang, Zhang, Hongfei, Li, Jin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264245/
https://ncbi.nlm.nih.gov/pubmed/25465805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-014-0608-y
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