A novel method for detection of HBVcccDNA in hepatocytes using rolling circle amplification combined with in situ PCR

BACKGROUND: Intrahepatic hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the original template for HBV replication. The persistence of cccDNA is responsible for the recurrence of HBV infection. The detection of cccDNA can help the development of new antiviral drugs against HBV rep...

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Gepubliceerd in:BMC Infect Dis
Hoofdauteurs: Zhong, Yanwei, Hu, Shuangye, Xu, Chen, Zhao, Yulai, Xu, Dongping, Zhao, Yanqing, Zhao, Jingmin, Li, Zhibin, Zhang, Xiuchang, Zhang, Hongfei, Li, Jin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264245/
https://ncbi.nlm.nih.gov/pubmed/25465805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-014-0608-y
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