Structure–Biological Function Relationship Extended to Mitotic Arrest-Deficient 2-Like Protein Mad2 Native and Mutants-New Opportunity for Genetic Disorder Control

Overexpression of mitotic arrest-deficient proteins Mad1 and Mad2, two components of spindle assembly checkpoint, is a risk factor for chromosomal instability (CIN) and a trigger of many genetic disorders. Mad2 transition from inactive open (O-Mad2) to active closed (C-Mad2) conformations or Mad2 bi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Avram, Speranta, Milac, Adina, Mernea, Maria, Mihailescu, Dan, Putz, Mihai V., Buiu, Catalin
Format: Artigo
Langue:Inglês
Publié: MDPI 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4264231/
https://ncbi.nlm.nih.gov/pubmed/25411801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms151121381
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