Dramatic Potentiation of the Antiviral Activity of HIV Antibodies by Cholesterol Conjugation

The broadly neutralizing antibodies HIV 2F5 and 4E10, which bind to overlapping epitopes in the membrane-proximal external region of the fusion protein gp41, have been proposed to use a two-step mechanism for neutralization; first, they bind and preconcentrate at the viral membrane through their lon...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Lacek, Krzysztof, Urbanowicz, Richard A., Troise, Fulvia, De Lorenzo, Claudia, Severino, Valeria, Di Maro, Antimo, Tarr, Alexander W., Ferrara, Francesca, Ploss, Alexander, Temperton, Nigel, Ball, Jonathan K., Nicosia, Alfredo, Cortese, Riccardo, Pessi, Antonello
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263897/
https://ncbi.nlm.nih.gov/pubmed/25342747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591826
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