Dramatic Potentiation of the Antiviral Activity of HIV Antibodies by Cholesterol Conjugation

The broadly neutralizing antibodies HIV 2F5 and 4E10, which bind to overlapping epitopes in the membrane-proximal external region of the fusion protein gp41, have been proposed to use a two-step mechanism for neutralization; first, they bind and preconcentrate at the viral membrane through their lon...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lacek, Krzysztof, Urbanowicz, Richard A., Troise, Fulvia, De Lorenzo, Claudia, Severino, Valeria, Di Maro, Antimo, Tarr, Alexander W., Ferrara, Francesca, Ploss, Alexander, Temperton, Nigel, Ball, Jonathan K., Nicosia, Alfredo, Cortese, Riccardo, Pessi, Antonello
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263897/
https://ncbi.nlm.nih.gov/pubmed/25342747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591826
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