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Conformational Response to Ligand Binding in Phosphomannomutase2: INSIGHTS INTO INBORN GLYCOSYLATION DISORDER
The most common glycosylation disorder is caused by mutations in the gene encoding phosphomannomutase2, producing a disease still without a cure. Phosphomannomutase2, a homodimer in which each chain is composed of two domains, requires a bisphosphate sugar (either mannose or glucose) as activator, o...
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Опубликовано в: : | J Biol Chem |
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Главные авторы: | , , , , , |
Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Society for Biochemistry and Molecular Biology
2014
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4263888/ https://ncbi.nlm.nih.gov/pubmed/25324542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586362 |
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