Conformational Response to Ligand Binding in Phosphomannomutase2: INSIGHTS INTO INBORN GLYCOSYLATION DISORDER

The most common glycosylation disorder is caused by mutations in the gene encoding phosphomannomutase2, producing a disease still without a cure. Phosphomannomutase2, a homodimer in which each chain is composed of two domains, requires a bisphosphate sugar (either mannose or glucose) as activator, o...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Andreotti, Giuseppina, Cabeza de Vaca, Israel, Poziello, Angelita, Monti, Maria Chiara, Guallar, Victor, Cubellis, Maria Vittoria
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Molecular Biophysics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263888/
https://ncbi.nlm.nih.gov/pubmed/25324542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586362
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