Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell depletion, microbial translocation and subsequent immune-activation, which remain elevated despite antiretroviral th...

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Pubblicato in:PLoS Pathog
Autori principali: Schuetz, Alexandra, Deleage, Claire, Sereti, Irini, Rerknimitr, Rungsun, Phanuphak, Nittaya, Phuang-Ngern, Yuwadee, Estes, Jacob D., Sandler, Netanya G., Sukhumvittaya, Suchada, Marovich, Mary, Jongrakthaitae, Surat, Akapirat, Siriwat, Fletscher, James L. K., Kroon, Eugene, Dewar, Robin, Trichavaroj, Rapee, Chomchey, Nitiya, Douek, Daniel C., O′Connell, Robert J., Ngauy, Viseth, Robb, Merlin L., Phanuphak, Praphan, Michael, Nelson L., Excler, Jean-Louis, Kim, Jerome H., de Souza, Mark S., Ananworanich, Jintanat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263756/
https://ncbi.nlm.nih.gov/pubmed/25503054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004543
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