Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell depletion, microbial translocation and subsequent immune-activation, which remain elevated despite antiretroviral th...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Schuetz, Alexandra, Deleage, Claire, Sereti, Irini, Rerknimitr, Rungsun, Phanuphak, Nittaya, Phuang-Ngern, Yuwadee, Estes, Jacob D., Sandler, Netanya G., Sukhumvittaya, Suchada, Marovich, Mary, Jongrakthaitae, Surat, Akapirat, Siriwat, Fletscher, James L. K., Kroon, Eugene, Dewar, Robin, Trichavaroj, Rapee, Chomchey, Nitiya, Douek, Daniel C., O′Connell, Robert J., Ngauy, Viseth, Robb, Merlin L., Phanuphak, Praphan, Michael, Nelson L., Excler, Jean-Louis, Kim, Jerome H., de Souza, Mark S., Ananworanich, Jintanat
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263756/
https://ncbi.nlm.nih.gov/pubmed/25503054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004543
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