Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes

RNA polymerase II (RNAPII) pausing/termination shortly after initiation is a hallmark of gene regulation. Here, we show that negative elongation factor (NELF) interacts with Integrator complex subunits (INTScom), RNAPII and Spt5. The interaction between NELF and INTScom subunits is RNA and DNA indep...

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Bibliografiske detaljer
Udgivet i:	Nat Commun
Main Authors:	Stadelmayer, Bernd, Micas, Gaël, Gamot, Adrien, Martin, Pascal, Malirat, Nathalie, Koval, Slavik, Raffel, Raoul, Sobhian, Bijan, Severac, Dany, Rialle, Stéphanie, Parrinello, Hugues, Cuvier, Olivier, Benkirane, Monsef
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Pub. Group 2014
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4263189/ https://ncbi.nlm.nih.gov/pubmed/25410209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6531
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Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes

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